Dear Colleagues,
It is our pleasure to welcome you to the European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases (AASLD) Joint Monothematic Conference on ”Nuclear Receptors and Liver Disease“ which will take place in Vienna, Austria from 27 February – 1 March 2009.
Nuclear Receptors are relevant for understanding hepatic physiology, pathophysiology, and adaptation to disease, regarding several major areas of basic liver function, including: bile acid transport and metabolism (cholestatic and gallstone disease), hepatic glucose and lipid metabolism (fatty liver disease and metabolic syndrome) and hepatic inflammation, fibrosis and liver cancer. Advances in our understanding of the role of nuclear receptors in liver disease are instrumental for the development of more effective medical therapies for these disorders. Several drugs in everyday clinical use already target nuclear receptors and the future will bring us more refined and specific therapeutic ligands tailored to help patients with these disorders. Central questions that will be addressed in this conference include:
- Roles for nuclear receptors in hepatic physiology and disease
- Gene regulation by nuclear receptors in bile formation and metabolism, cholestatic liver disease, gallstone disease
- Roles for nuclear receptors in hepatic drug metabolism and xenobiotic transformation, hepatotoxicity and drug interactions
- Roles for of nuclear receptors in hepatic lipid metabolism, fatty liver disease, hepatic inflammation, fibrosis, liver regeneration and liver cancer
- Design and application of nuclear receptor ligands as effective therapeutic agents
We look forward to seeing you in Vienna in February for this exciting scientific event!
Sincerely,
Michael Trauner Saul J. Karpen
Organising Committee