Animal Models of VaD
• Spontaneously Hypertensive Rat as a Model of Vascular Brain Disorder: Microanatomical, Behavioral
and Neurochemical Evidence
• Vascular Cognitive Impairment (VCI): Clinical Cardiovascular Risk Factors and Neurobehavioral Phenotypes
are Mimicked in Hypertensive Rat VCI Model
• The Cholinergic Approach in the Treatment of Vascular Dementia
• In Vivo Models of Human Cerebral Small Vessel Disease
• Potential Animal Models of Lacunar Stroke – relevance to small vessel pathology and brain tissue lesions
Advances in Pathogenesis of SVD Behavioral Problems in VaD
• Vasoregulatory changes
• Insights from genome-wide association studies
• Is blood brain barrier breakdown important – lessons from neuropathology
• Is blood brain barrier breakdown important – lessons from MRI
Cerebral Amyloid Angiopathy and Amyloid Lowering Therapy
TBA
Cerebral Hemodynamics and Cognitive Impairment
• Carotid artery disease and cognitive impairment
• Cerebrovascular reactivity and cognitive impairment
• Cerebral microemboli and cognitive impairment
Criteria and Clinimetric Scales
TBA
Dementia Prevention
• Pre-DIVA Study
• Finish Geriatric Intervention to Prevent Cognitive Impairment and Disability (FINGER Study)
• MAPT Study
• LipiDIDiet
Diabetes, Insulin and Cognitive Impairment
TBA
Diagnostic and Biomarkers in Vascular Cognitive Impairment
• CSF Biomarkers for clinical studies of dementia
• Structural MR imaging as a diagnostic and biomarker of VCI
• PET/SPECT and Amyloid imaging
• Functional Techniques
Future Directions in Interventions for Cognitive Impairment
TBA
Gait & Cognitive Impairment
• Introduction and epidemiological/evidence for gait/cognition Links
• Association of traditional and novel cardiac markers with motor and cognitive decline
• The interplay between motor function and cognition in aging and dementia
• Cognitive therapy and virutal reality for gait and mobility in aging and patients with cognitive impairment
• Traditional and emerging rehabilitation approaches to improve
mobility in vascular patients
Immunological Factors in the Pathogenesis of AD and VaD
• Implication of Fc Receptors in AD
• The role of anti- gangliosides antibodies in the pathophysiology of dementia
• Abnormal systemic networks of intercellular communicome proteins in Alzheimer s disease
• The role of inflammatory, genetic and vascular factors in Alzheimer’s disease
• Nuclear pore complex proteins in neurodegeneration
MCI
• Cognitive disorders at type 2 diabetes mellitus
• Cognitive disorders at atherosclerosis stenosis of carotid arteries
• Post-stroke cognitive disorders
• Cholinergic-glutamatergic combination therapy in early stage vascular and mixed dementia
Metabolic Risk Factors and Dementia
TBA
Microbleeds and Cognition
• Introductory remarks
• Neuropathological aspects of microbleeds and the reliability to detect them in postmortem brain sections with
a 7.0 Tesla MRI
• Cerebral microbleeds and cognition in cerebrovascular disease
• Clinical aspects of microbleeds in Alzheimer’s disease
Neuropathology
• Vascular basis for brain degeneration
• Vascular pathology - a neuropathologists approach
• The significance of small cerebral bleeds in different neurodegenerative dementia syndromes
• Ethnic-based susceptibility to AD and VaD – a genetic approach
Plenary Sessions
• Vascular cognitive impairment – an ill-defined concept with the need to define its vascular component
• Binswanger disease and Lower body Parkinson
• Secular changes in vascular cognitive impairment
• The most prevalent and least well understood genetic factor for dementia, APOG
• WML – Angiopathy related or not
• The neurovascular unit and dementia
• Stress- metabolic and structural mechanisms in vascular dementia
· Is vascular depression really incipient dementia?
• MCI: Can we identify prodromal vascular dementia?
• Do we need to change our paradigm of Dementia
• What are the resistance factors against dementia & how do they operate?
· Is the effect of diabetes on cognition mediated by amyloid and vascular effects only?
Post Stroke Cognitive Impairment
• Neuropsychological treatment for patients with post-stroke cognitive-behavioral focal deficits
• Music as an aid in the treatment of post-stroke disorders
• Pharmacological interventions in neurorehabilitation after stroke
Rare Causes of Vascular Cognitive Impairment
• Genetic Neurometabolic Vascular Dementia: from bed to laboratory and contrary
• New genetic approach to vascular dementias
• Other rare forms of Vascular Dementia
Satellite Symposium – Nycomed - Neuroprotection in Vascular Dementia: how far should we go?
• Epidemiology of cognitive disorders: do we face a challenge?
• Lessons learned in vascular dementia
• Actovegin: past, present, future
Satellite Symposium - SSNN
• Practice versus theory in vascular cognitive impairment treatment
• Multimodal molecules for heterogeneous disorders
• A hope for neuroregeneration in neurodegeneration
Similar Pathobiochemical Mechanisms of AD and VaD
• Mitochondrial diseases as a model of neurodegeneration
• Mitochondria and the vasculature
• Mitochondria and Alzhemer's disease
• Mitochondrial disturbances, excitotoxicity and kynurenines: novel therapeutic strategies
Stress & Dementia
• Physical activity and neuroplasticity
• Food for thought-importance of vitamins and antioxidants intake
• Stress and stroke
• Aging and brain fitness
Susac's Syndrom
• A Brief Review of Susac's syndrome
• The International Collaborative Study (ICS) of Susac's syndrome
• The Patience and Impatience of patients -A Patient Panel Presentation
• Questions, Answers, and Discussion
The Significance of Vascular Burden in Old Age
• Assessing the relationship between cardiovascular risk factors and cognitive decline
• The cortical disconnection theory in old age
• Small macrovascular and microvascular pathology in late-life
• Vascular amyloid load in old age: epiphenomenon or primum movens?
Vascular Depression
• Cognitive and affective characteristics therapeutic dynamics in co-morbidity of cerebrovascular disease
and depression
• Interfaces of cerebrovascular disease and depression
• Post-stroke depression: a bridge between dementia and affective disorder?