Jesse Roth is Professor of Medicine, Albert Einstein College of Medicine, Division of Endocrinology, Associate Director, General Clinical Research Center (NIH, GCRC), at the Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System.

Dr. Roth is a graduate of Columbia University in New York, and received his M.D. degree from Albert Einstein College of Medicine in New York. He trained in Internal Medicine at Barnes Hospital, Washington University in St. Louis, followed by a fellowship at the Bronx VA Medical Center in New York, under Nobel Prize Laureates Solomon Berson and Roslyn Yallow.

Dr. Jesse Roth served for nearly two decades in a leadership capacity at the National Institute of Diabetes, and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH). He started as Clinical Associate, and moved on to Senior Investigator, Chief Diabetes Section, Chief Diabetes Branch, and finally Scientific Director NIDDK. During part of this period at NIH Dr. Roth served also as Assistant Surgeon General, U.S. Public Health Service. Dr. Roth has introduced the direct study of cell surface receptors, leading to the recognition of the vital role of these receptors in transforming the information provided by extracellular hormonal signals into intracellular events. He played an important role in uncovering the first few steps in insulin action and understanding the role of these events in genetic and acquired disorders of glucose metabolism. Jesse pioneered in the measurement of circulating levels of human growth hormone with introduction of tests for management of patients with Acromegaly and growth hormone deficiency that remain valid and useful.

After leaving the NIH Dr. Roth was appointed Raymond and Anna Lublin Professor of Medicine, Johns Hopkins University School of Medicine; Director, Division of Geriatric Medicine and Gerontology; Director, Johns Hopkins Center on Aging. He subsequently became President and CEO, Picower Institute for Medical Research; Professor, Picower Graduate School of Molecular Medicine, and Editor-in-Residence, Molecular Medicine (official publication of Molecular Medicine Society). He left the institute to become Geriatrician-in-Chief, North Shore-Long Island Jewish Health System, a position he holds to date.

Dr. Roth won numerous honors and awards: He is Past-President, American Society for Clinical investigation. He received honorary doctorates from The University of Uppsala, Sweden, Yeshiva University in New York, and the University of Rome.  Distinguished Service Medal of the U.S. Public Health Service, Gairdner Foundation Annual Award for Scientific Excellence, A.C. Morrison Award In Natural Sciences, N.Y. Academy of Science, for a body of outstanding research. He gave the 1982 Harvey Lecture, and got the 1982 Banting Medal, American Diabetes Association, highest award for scientific achievement. In 1985 he got the Koch Award, Endocrine Society, highest award for scientific achievement. The National Medical Research Award of the National Health Council (for scientific achievement), 1993 Albert Renold Award, American Diabetes Association (for outstanding mentoring of young researchers), 2001 Endocrine Society: Robert H. Williams Distinguished Leadership Award. Dr. Roth is a fellow of the American Academy of Arts and Sciences and the American Association for the Advancement of Science. He is a scientific reviewer and member of Board of Governors Weizmann Institute of Science. In 2006 he was elected honorary member of EASD (European Association for the Study of Diabetes).

Dr. Roth has had a great impact on scientific research. He has published more than 400 articles, some of which have been declared "citation classics". He was listed by Current Contents among the most cited authors on multiple occasions.  He serves as editor, or member of the editorial board of several leading journals in the fields of diabetes, endocrinology & metabolism, and aging.