The burden of alcohol-related disease is important throughout the world. Studies show that particularly harmful drinking habits are spreading from the north to all parts of Europe. The epidemiology of alcohol-related disease is changing in keeping with changing patterns of alcohol consumption. A strong increase in binge drinking is currently being seen in western countries and constitutes a major public health problem. The interactions between alcohol and genetic factors and co-morbidities such as obesity have become clearer. Non-invasive methods to screen for fibrosis open up new era for evaluation of patients with alcoholic liver disease. In a broader context there are differing opinions regarding the optimal social and public health measures required to reduce alcohol-related harm and alcoholic liver disease specifically. It is in this context of exciting recent advancements, social challenges and clinical controversy that we invite you to this EASL Monothematic Conference on Alcoholic Liver Disease.